Development and characterization of cold-adapted viruses for use as live virus vaccines
Identifieur interne : 002447 ( Main/Exploration ); précédent : 002446; suivant : 002448Development and characterization of cold-adapted viruses for use as live virus vaccines
Auteurs : H. F. Maassab [États-Unis] ; Dan C. Deborde [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 1985.
English descriptors
- Teeft :
- Absent coryza, Academic press, Adaptation, Adult volunteers, Animal model system, Animal virus, Animal viruses, Application branch, Asian strain, Attenuated, Attenuated influenza, Attenuated phenotype, Attenuated strain, Attenuated strains, Attenuated type, Attenuated virus, Attenuation, Average duration, Biological properties, Chanock, Chick, Clone, Cold adaptation, Cold adaptation process, Cold mutants, Cold reassortant, Cold reassortants, Cold variant, Cold variant virus, Cold variants, Coldadapted, Coldadapted viruses, Constellation, Deborde, Deborde table, December, Defensive role, Different strains, Disease control, Donor line, Donor virus, Embryonated, Embryonated eggs, Encephalitis, Encephalitis virus vaccines, Fewer passages, Flow diagram, Gene, Gene composition, Gene constellation, Genes coding, Genetic, Genetic constitution, Genetic markers, Genetic stability, Genus, Growth characteristics, Hamster, Herpes simplex type, High temperature, Higher temperatures, Host cell, Host factors, Human volunteers, Immun, Immune serum, Incubation temperature, Infectious diseases, Infectivity, Influenza, Influenza reassortants, Influenza type, Influenza vaccine, Influenza virus, Influenza virus type, Influenza virus vaccine, Influenza virus vaccines, Influenza viruses, Inoculated, Inoculated intranasally, Intermediate temperature, Intranasal inoculation, Irregular boundary, Kendal, Lds0 titres, Lesion, Lower temperature, Lower temperatures, Maassab, Marker, Marker time postinfection, Master strain, Mdck cells, Monkey kidney cells, Mosquito, Mouse virulence, Multiple lesions, Mutant, National institute, Necrotic lesions, Negative strand viruses, Neutralizing antibody, Normal host, Optimal growth, Original strain, Parainfluenza, Parainfluenza type, Parainfluenza virus, Parainfluenza virus type, Parental, Parental lcmv, Parental virus, Passage history, Passaged, Personal communication, Phenotype, Pilot studies, Plaque, Plaque formation, Plaque morphology, Plaque size, Plaque titration, Pneumococcus type, Polio, Poliovirus, Poliovirus vaccines, Quail embryo fibroblasts, Rabies virus, Reactogenicity, Reassortant, Reassortants, Reassortment, Recombinant, Recombinant influenza, Replication, Reproductive capacity, Respiratory syncytial virus, Reversion, Rhabdovirus genus, Serial passage, Serial passages, Serially passaged, Several groups, Significant change, Simplex, Single genes, Successive passages, Suckling mice, Surface antigens, Syncytial virus, Temperature mutants, Temperature sensitivity, Temperatures passage, Tissue culture, Turbinate, Vaccine, Vaccine candidate, Vaccine line, Vaccine virus, Vaccinia virus, Variant, Various temperatures, Vesicular stomatitis virus, Vigorous growth, Viral replication, Virol, Virulence, Virulent, Virulent strains, Virus, Virus genera, Virus growth, Virus infectivity, Virus line, Virus strain, Virus vaccine, Virus vaccine candidates, Virus vaccine line, Virus vaccines, Wild type, Wild type parent, Wild type virus.
Abstract
Abstract: Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected. In addition, the starting virus should be a recent isolate not as yet adapted to a tissue culture host and the cold-adaptation process should then occur in a host heterologous to the virus' normal host. These viruses have been reviewed in the light of their cold-adaptation method and successful production of an attenuated line as virus vaccine candidate. Finally, detailed information is presented for the cold-adaptation process in influenza virus.
Url:
DOI: 10.1016/0264-410X(85)90124-0
Affiliations:
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- to stream Main, to step Curation: 002447
Le document en format XML
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<term>Disease control</term>
<term>Donor line</term>
<term>Donor virus</term>
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<term>Encephalitis virus vaccines</term>
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<front><div type="abstract" xml:lang="en">Abstract: Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected. In addition, the starting virus should be a recent isolate not as yet adapted to a tissue culture host and the cold-adaptation process should then occur in a host heterologous to the virus' normal host. These viruses have been reviewed in the light of their cold-adaptation method and successful production of an attenuated line as virus vaccine candidate. Finally, detailed information is presented for the cold-adaptation process in influenza virus.</div>
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